The Future of Crohn's Treatment

Researchers are learning more about the causes behind Crohn's disease, which may lead to future therapies for treatment.

The Future of Crohn's Treatment

By Crohn's Connect Staff Published at July 28, 2014 Views 2,084 Likes 1

While the causes of Crohn's disease are unknown, one popular theory is that it is the result of an attack on the immune system, which is responsible for regulating good and bad microbes. Due to an inability to distinguish between the two, the body will fight off good microbes in Crohn's patients. This may be due to a newly discovered mutation of a well-known protein, according to recent research.

Catherine Leimkuhler Grimes, an assistant professor at the University of Delaware, and Vishnu Mohanan, a doctoral student of biological sciences at UD, identified NOD2, a protein that has been linked to Crohn's disease in a number of studies.

"We want to figure out why the mutation of NOD2 results in an increase in inflammation," Mohanan said in a statement. "Right now, we have limited knowledge. Once the signaling mechanism is figured out, we will have the keystone."

So far, the colleagues have found that other proteins are responsible for stabilizing NOD2, which prevents the body from getting rid of the inflammation-causing substance. However, it is not yet clear what these other proteins are. If further research is able to uncover these unknowns, the authors believe that scientists will have a greater opportunity to develop therapies that are successful in treating Crohn's disease.

Current Treatment Options

So what are your current options for living with Crohn's disease? According to the Crohn's & Colitis Foundation of America, many doctors will recommend medication, changes in lifestyle or surgery. In fact, the source reported that nearly 70 percent of patients with Crohn's eventually require surgery for their condition. However, you may want to address symptoms related to the disease naturally by paying special attention to your diet. For instance, high-fiber and spicy foods may increase the number of flare-ups you experience. Additionally, you can talk to your doctor about different medications that may help to reduce your symptoms as well.

To learn more about living with Crohn's Disease:

Women Stand Up Against Crohn's Disease
10 Best Foods for Crohn’s Disease
4 Things Crohn’s Disease Has Taught Me about Life

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